diff --git a/Lib/python/embed.i b/Lib/python/embed.i
index 505dd9b57..3fc2d14e5 100644
--- a/Lib/python/embed.i
+++ b/Lib/python/embed.i
@@ -29,7 +29,7 @@ As far as I know, this module is C++ safe.
 #endif
 
 %wrapper %{
-#ifndef SWIG_NO_PY_SSIZE_T_CLEAN
+#if !defined(PY_SSIZE_T_CLEAN) && !defined(SWIG_NO_PY_SSIZE_T_CLEAN)
 #define PY_SSIZE_T_CLEAN
 #endif
 
diff --git a/Lib/python/pyruntime.swg b/Lib/python/pyruntime.swg
index aa2ecfe08..1d028adaf 100644
--- a/Lib/python/pyruntime.swg
+++ b/Lib/python/pyruntime.swg
@@ -4,7 +4,7 @@
 # include <math.h>
 #endif
 
-#ifndef SWIG_NO_PY_SSIZE_T_CLEAN
+#if !defined(PY_SSIZE_T_CLEAN) && !defined(SWIG_NO_PY_SSIZE_T_CLEAN)
 #define PY_SSIZE_T_CLEAN
 #endif