diff --git a/.github/workflows/ci.yml b/.github/workflows/ci.yml
index 427c5c381..2166d9879 100644
--- a/.github/workflows/ci.yml
+++ b/.github/workflows/ci.yml
@@ -67,6 +67,10 @@ jobs:
         - SWIGLANG: go
           VER: '1.17'
         - SWIGLANG: guile
+        - SWIGLANG: guile
+          VER: '2.2'
+        - SWIGLANG: guile
+          VER: '3.0'
         - SWIGLANG: java
         - SWIGLANG: javascript
           ENGINE: node
diff --git a/Doc/Manual/Guile.html b/Doc/Manual/Guile.html
index f72a4287b..5a95f3b7d 100644
--- a/Doc/Manual/Guile.html
+++ b/Doc/Manual/Guile.html
@@ -52,9 +52,10 @@ This section details guile-specific support in SWIG.
 
 
 <p>
-SWIG works with Guile versions 1.8.x and 2.0.x. Support for version
-1.6.x has been dropped. The last version of SWIG that still works with
-Guile version 1.6.x is SWIG 2.0.9.
+SWIG is known to work with Guile versions 2.0.x, 2.2.x and 3.0.x. We believe
+it still works with 1.8.x, but we're no longer able to easily test this.
+Support for version 1.6.x has been dropped. The last version of SWIG that still
+works with Guile version 1.6.x is SWIG 2.0.9.
 
 <p>
 Note that starting with guile 2.0, the guile sources can be compiled for
diff --git a/Examples/test-suite/guile/guile_ext_test_external.cxx b/Examples/test-suite/guile/guile_ext_test_external.cxx
index c4f906a97..2729537bd 100644
--- a/Examples/test-suite/guile/guile_ext_test_external.cxx
+++ b/Examples/test-suite/guile/guile_ext_test_external.cxx
@@ -19,6 +19,6 @@ SCM test_create()
 SCM test_is_pointer(SCM val)
 {
 #define FUNC_NAME "test-is-pointer"
-  return SCM_BOOL(SWIG_IsPointer(val));
+  return scm_from_bool(SWIG_IsPointer(val));
 #undef FUNC_NAME
 }
diff --git a/Lib/guile/guile_scm_run.swg b/Lib/guile/guile_scm_run.swg
index 84444e33e..3752d3c8a 100644
--- a/Lib/guile/guile_scm_run.swg
+++ b/Lib/guile/guile_scm_run.swg
@@ -131,7 +131,7 @@ SWIG_Guile_NewPointerObj(void *ptr, swig_type_info *type, int owner)
     else
       SCM_NEWSMOB2(smob, swig_tag, ptr, (void *) type);
 
-    if (!cdata || SCM_NULLP(cdata->goops_class) || swig_make_func == SCM_EOL ) {
+    if (!cdata || scm_is_null(cdata->goops_class) || swig_make_func == SCM_EOL ) {
       return smob;
     } else {
       /* the scm_make() C function only handles the creation of gf,
@@ -151,7 +151,7 @@ SWIGINTERN unsigned long
 SWIG_Guile_PointerAddress(SCM object)
 {
   SCM smob = SWIG_Guile_GetSmob(object);
-  if (SCM_NULLP(smob)) return 0;
+  if (scm_is_null(smob)) return 0;
   else if (SCM_SMOB_PREDICATE(swig_tag, smob)
 	   || SCM_SMOB_PREDICATE(swig_collectable_tag, smob)
 	   || SCM_SMOB_PREDICATE(swig_destroyed_tag, smob)) {
@@ -164,7 +164,7 @@ SWIGINTERN swig_type_info *
 SWIG_Guile_PointerType(SCM object)
 {
   SCM smob = SWIG_Guile_GetSmob(object);
-  if (SCM_NULLP(smob)) return NULL;
+  if (scm_is_null(smob)) return NULL;
   else if (SCM_SMOB_PREDICATE(swig_tag, smob)
 	   || SCM_SMOB_PREDICATE(swig_collectable_tag, smob)
 	   || SCM_SMOB_PREDICATE(swig_destroyed_tag, smob)) {
@@ -192,7 +192,7 @@ SWIG_Guile_ConvertPtr(SCM s, void **result, swig_type_info *type, int flags)
   swig_type_info *from;
   SCM smob = SWIG_Guile_GetSmob(s);
 
-  if (SCM_NULLP(smob)) {
+  if (scm_is_null(smob)) {
     *result = NULL;
     return (flags & SWIG_POINTER_NO_NULL) ? SWIG_NullReferenceError : SWIG_OK;
 #if SCM_MAJOR_VERSION >= 2
@@ -258,7 +258,7 @@ SWIGINTERN void
 SWIG_Guile_MarkPointerNoncollectable(SCM s)
 {
   SCM smob = SWIG_Guile_GetSmob(s);
-  if (!SCM_NULLP(smob)) {
+  if (!scm_is_null(smob)) {
     if (SWIG_Guile_IsValidSmob(smob)) {
       SCM_SET_CELL_TYPE(smob, swig_tag);
     }
@@ -271,7 +271,7 @@ SWIGINTERN void
 SWIG_Guile_MarkPointerDestroyed(SCM s)
 {
   SCM smob = SWIG_Guile_GetSmob(s);
-  if (!SCM_NULLP(smob)) {
+  if (!scm_is_null(smob)) {
     if (SWIG_Guile_IsValidSmob(smob)) {
       SCM_SET_CELL_TYPE(smob, swig_destroyed_tag);
     }
@@ -492,20 +492,20 @@ SWIG_Guile_GetArgs (SCM *dest, SCM rest,
   int i;
   int num_args_passed = 0;
   for (i = 0; i<reqargs; i++) {
-    if (!SCM_CONSP(rest))
+    if (!scm_is_pair(rest))
       scm_wrong_num_args(scm_from_utf8_string(procname ? (char *) procname : "unknown procedure"));
     *dest++ = SCM_CAR(rest);
     rest = SCM_CDR(rest);
     num_args_passed++;
   }
-  for (i = 0; i<optargs && SCM_CONSP(rest); i++) {
+  for (i = 0; i<optargs && scm_is_pair(rest); i++) {
     *dest++ = SCM_CAR(rest);
     rest = SCM_CDR(rest);
     num_args_passed++;
   }
   for (; i<optargs; i++)
     *dest++ = SCM_UNDEFINED;
-  if (!SCM_NULLP(rest))
+  if (!scm_is_null(rest))
       scm_wrong_num_args(scm_from_utf8_string(procname ? (char *) procname : "unknown procedure"));
   return num_args_passed;
 }
diff --git a/Lib/guile/typemaps.i b/Lib/guile/typemaps.i
index 4ad1aefa8..eb0a41422 100644
--- a/Lib/guile/typemaps.i
+++ b/Lib/guile/typemaps.i
@@ -425,7 +425,7 @@ typedef unsigned long SCM;
 %typecheck(SWIG_TYPECHECK_BOOL)
 	bool, bool&, const bool&
 {
-  $1 = SCM_BOOLP($input) ? 1 : 0;
+  $1 = scm_is_bool($input) ? 1 : 0;
 }
 
 %typecheck(SWIG_TYPECHECK_DOUBLE)
diff --git a/Tools/CI-linux-install.sh b/Tools/CI-linux-install.sh
index 525121e8c..ea811f506 100644
--- a/Tools/CI-linux-install.sh
+++ b/Tools/CI-linux-install.sh
@@ -62,7 +62,7 @@ case "$SWIGLANG" in
 		esac
 		;;
 	"guile")
-		$RETRY sudo apt-get -qq install guile-2.0-dev
+		$RETRY sudo apt-get -qq install guile-${VER:-2.0}-dev
 		;;
 	"lua")
 		if [[ -z "$VER" ]]; then